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Related Experiment Videos

Human spinal ejaculation generator.

Clément Chéhensse1, Patricia Facchinetti1, Stéphane Bahrami2,3

  • 1Université de Versailles St-Quentin en Yvelines, Inserm UMR 1179, Montigny-le-Bretonneux, France.

Annals of Neurology
|December 6, 2016
PubMed
Summary

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This summary is machine-generated.

Scientists found a human spinal ejaculation generator (SEG) in the L3-L5 spinal segments, similar to rats. This discovery, involving galaninergic neurons, could lead to new treatments for ejaculation disorders.

Area of Science:

  • Neuroscience
  • Urology
  • Human Anatomy

Background:

  • A spinal ejaculation generator (SEG) involving galaninergic interneurons was previously identified in rats.
  • Understanding the human SEG is crucial for treating ejaculatory dysfunction.

Purpose of the Study:

  • To investigate the existence and characteristics of a SEG in the human spinal cord.
  • To determine if sexual dimorphism exists in the human SEG.

Main Methods:

  • Spatial distribution of galaninergic neurons was analyzed in postmortem spinal cord segments from men and women.
  • The impact of spinal cord injury on ejaculation following penile vibratory stimulation was studied in 384 patients.

Main Results:

  • Galaninergic neurons were predominantly found in human spinal segments L2-L5, with higher density in men, indicating sexual dimorphism.

Related Experiment Videos

  • Injury to L3-L5 segments was the only predictor of failed ejaculation after penile vibratory stimulation in patients with spinal cord injury.

    • Conclusions:

    • Neuroanatomical and clinical findings support the existence of a human SEG in spinal segments L3-L5.
    • The human SEG shares organizational and sexual dimorphic similarities with the rat SEG.
    • Targeting the human SEG may offer therapeutic potential for various ejaculatory disorders.