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Related Experiment Video

Updated: Mar 10, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Familial aggregation in developmental topographical disorientation (DTD).

Sarah F Barclay¹, Ford Burles², Kendra Potocki²

¹a Department of Medical Genetics and Alberta Children's Hospital Research Institute, Cumming School of Medicine , University of Calgary , Calgary , AB , Canada.

Cognitive Neuropsychology

|December 8, 2016

Summary

Developmental topographical disorientation (DTD), a lifelong inability to navigate, appears to run in families. This study found DTD clusters in affected families, suggesting a potential genetic basis for this spatial navigation disorder.

Keywords:

Genetics getting lost heredity navigation spatial orientation

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Published on: November 21, 2013

Area of Science:

Neuroscience
Human Genetics
Cognitive Psychology

Background:

Acquired topographical disorientation results from brain lesions.
Developmental topographical disorientation (DTD) is a lifelong spatial navigation deficit present without apparent brain abnormalities.
DTD may have a familial component, as affected individuals often report relatives with similar difficulties.

Purpose of the Study:

To investigate the familial aggregation of developmental topographical disorientation (DTD).
To determine if DTD occurs more frequently in the families of individuals with DTD compared to control families.

Main Methods:

Assessed the occurrence of DTD in the families of probands diagnosed with DTD.
Assessed the occurrence of DTD in the families of control probands without topographical disorientation.
Compared the rates of DTD between the DTD and control family groups.

Main Results:

DTD was found to cluster within the families of DTD probands.
Tested relatives of DTD probands frequently exhibited the trait.
No individuals with DTD were detected in the families of control probands.

Conclusions:

These findings provide the first evidence for the familial clustering of DTD.
The familial aggregation of DTD suggests a potential genetic contribution to the condition.
Further research is warranted to explore the genetic factors underlying DTD.