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Relapsed Burkitt Lymphoma Presenting as an Isolated Infiltrative Optic Neuropathy.

Shiraaz I Rahman¹, Joshua K Fernandes¹, Manjot K Gill¹

¹Department of Ophthalmology, Northwestern University , Chicago, Illinois, USA.

Neuro-Ophthalmology (Aeolus Press)

|December 9, 2016

Summary

Relapsed sporadic Burkitt lymphoma (BL) can present as isolated optic neuropathy, a rare recurrence sign. This case highlights the importance of considering lymphoma relapse in patients with unexplained visual loss.

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Area of Science:

Ophthalmology
Oncology
Neurology

Background:

Sporadic Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma.
Relapsed BL typically presents with systemic or nodal involvement.
Optic neuropathy can have diverse etiologies, including neoplastic infiltration.

Observation:

A patient with a history of sporadic BL presented with isolated infiltrative optic neuropathy.
The optic neuropathy was the sole clinical manifestation of disease recurrence.
Ophthalmologic examination revealed signs consistent with infiltrative optic nerve involvement.

Findings:

This case represents the first reported instance of isolated infiltrative optic neuropathy as the sole indicator of sporadic BL recurrence.
The findings suggest that neoplastic infiltration of the optic nerve can occur without other signs of systemic relapse.

Keywords:

Burkitt lymphoma non-Hodgkin lymphoma ocular lymphoma optic neuropathy

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Diagnostic workup confirmed Burkitt lymphoma infiltration of the optic nerve.

Implications:

Clinicians should consider the possibility of lymphoreticular malignancy relapse in patients presenting with acute visual symptoms suggestive of optic neuropathy.
Ophthalmologists and oncologists should be aware of this rare presentation of BL recurrence.
Early recognition and diagnosis are crucial for timely management of relapsed BL presenting with optic neuropathy.