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Related Concept Videos

Ethics and Bioethics01:22

Ethics and Bioethics

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Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
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Ethical Issues01:27

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Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Nursing Ethical Principles II01:27

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Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
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Ethical Dilemmas II01:30

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Resolving an ethical dilemma in healthcare involves a systematic approach that considers every aspect of the issue, respecting both the patient's needs and values and the healthcare professional's ethical obligations. Here are potential steps to resolve an ethical dilemma:
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Ethical Dilemmas I01:17

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Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
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Implementing Precision Medicine: The Ethical Challenges.

Diane M Korngiebel1, Kenneth E Thummel2, Wylie Burke3

  • 1Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.

Trends in Pharmacological Sciences
|December 13, 2016
PubMed
Summary
This summary is machine-generated.

Precision medicine uses genetic insights to personalize healthcare, with pharmacogenomics and cancer genetics guiding drug choices and inherited cancer risk assessment. Ongoing research must address evidence gaps and diversity to ensure trustworthy clinical implementation.

Keywords:
cancer geneticsclinical decision supportimplementation sciencepharmacogenomicsprecision medicine

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Area of Science:

  • Genomics
  • Personalized Medicine
  • Clinical Pharmacology

Background:

  • Precision medicine tailors healthcare based on individual genetic, lifestyle, and environmental variations.
  • Pharmacogenomics and cancer genetics are key areas for personalized care, impacting drug efficacy and disease prevention.

Purpose of the Study:

  • To highlight the potential of pharmacogenomic and cancer genetic testing in clinical practice.
  • To identify challenges in implementing these tests and suggest research priorities.

Main Methods:

  • Review of current applications and development status of pharmacogenomic and cancer genetic tests.
  • Analysis of implementation challenges, including evidence base and population diversity.

Main Results:

  • A few pharmacogenomic and cancer genetic tests are in clinical use, with more under development.
  • Limited evidence and lack of diverse population data pose significant implementation hurdles.

Conclusions:

  • Further research should focus on improving the trustworthiness of clinical guidelines and developing decision support tools for clinicians and patients.
  • Ethical considerations are integral to the implementation of precision medicine strategies.