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Titanium Dioxide in Toothpaste Causing Yellow Nail Syndrome.

Ting-Yuan Hsu1, Chun-Chen Lin1,2,3, Ming-Dar Lee1,2

  • 1Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan.

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Summary
This summary is machine-generated.

Yellow nail syndrome (YNS) is a rare disorder. This case report highlights a pediatric YNS patient with nail discoloration and respiratory issues linked to titanium exposure from toothpaste, with symptoms improving after avoidance.

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Area of Science:

  • Pediatric Medicine
  • Dermatology
  • Pulmonology

Background:

  • Yellow nail syndrome (YNS) is characterized by yellow nails, lymphedema, and respiratory issues.
  • Pediatric cases of YNS are infrequently reported in medical literature.
  • Previous research suggests a potential link between YNS and titanium exposure.

Observation:

  • A 9-year-old girl presented with a year of yellowish nail discoloration and significant respiratory symptoms.
  • Diagnostic evaluation confirmed Yellow Nail Syndrome (YNS).
  • Titanium was detected in her nail clippings, with potential exposure from ingesting children's toothpaste.

Findings:

  • The patient experienced symptom improvement, including nail discoloration and respiratory issues, after ceasing toothpaste ingestion.
  • Follow-up nail clippings showed no detectable titanium 3 years later.
  • This case establishes a direct relationship between titanium exposure and YNS symptoms in a pediatric patient.

Implications:

  • Avoiding titanium exposure, particularly in children, may alleviate Yellow Nail Syndrome symptoms.
  • This study underscores the importance of considering environmental exposures in pediatric YNS cases.
  • Further research is warranted to explore the mechanism linking titanium and YNS pathogenesis.