Synthesis of 3-Fluoroindoles via Photoredox Catalysis
Liubov I Panferova1, Vladimir O Smirnov1, Vitalij V Levin1
1N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , Leninsky prosp. 47, 119991 Moscow, Russian Federation.
Abstract:
A method for the synthesis of 3-fluoroindoles from N-arylamines substituted with the CF2I group is described. The reaction is mediated by a ruthenium photocatalyst in the presence of a substoichiometric amount of triphenylphosphine upon irradiation with blue light. The starting N-arylamines are readily obtained by nucleophilic iododifluoromethylation of iminium ions.
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