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Plasmodium vivax Controlled Human Malaria Infection - Progress and Prospects
Ruth O Payne1, Paul M Griffin2, James S McCarthy3
1The Jenner Institute Laboratories, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK; The Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, OX3 7LE, UK.
Trends in Parasitology
|December 14, 2016
Summary
Controlled human malaria infection (CHMI) models using Plasmodium vivax are emerging. These models will accelerate the development of new malaria drugs and vaccines, similar to Plasmodium falciparum studies.
Area of Science:
- * Malariology
- * Infectious Diseases
- * Clinical Trials
Background:
- * Controlled human malaria infection (CHMI) trials predominantly use Plasmodium falciparum.
- * Renewed interest in Plasmodium vivax necessitates adapted CHMI models.
- * CHMI models are crucial for understanding host-pathogen interactions and intervention efficacy.
Purpose of the Study:
- * To review and compare existing Plasmodium vivax CHMI models.
- * To examine the advantages and disadvantages of different Plasmodium vivax CHMI approaches.
- * To highlight the potential of Plasmodium vivax CHMI for accelerating drug and vaccine development.
Main Methods:
- * Review of published literature on Plasmodium vivax CHMI models.
- * Analysis of infection initiation methods: mosquito bite versus blood-stage inoculum.
- * Comparison of model characteristics across different research groups (Colombia, USA, Australia).
Main Results:
- * Development of Plasmodium vivax CHMI models in multiple international research settings.
- * Identification of varied approaches for initiating infection in Plasmodium vivax CHMI.
- * Established Plasmodium falciparum CHMI models provide a benchmark for Plasmodium vivax development.
Conclusions:
- * Plasmodium vivax CHMI models are now available for clinical research.
- * These models offer a platform for early-stage testing of interventions against Plasmodium vivax.
- * CHMI studies will expedite the development of novel drugs and vaccines for malaria caused by Plasmodium vivax.
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