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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
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Acute respiratory distress syndrome
Christopher Mason1, Nessa Dooley2, Mark Griffiths3
1Barts Heart Centre, St Bartholomew's Hospital, London, UK.
Clinical Medicine (London, England)
|December 14, 2016
Summary
Acute respiratory distress syndrome (ARDS) is underdiagnosed and leads to high mortality and disability. Quality improvement measures can prevent severe ARDS progression by minimizing iatrogenic injury.
Area of Science:
- Critical care medicine
- Pulmonology
- Patient safety
Background:
- Acute respiratory distress syndrome (ARDS) is a frequent cause of acute respiratory failure.
- ARDS is often underdiagnosed in and out of intensive care units.
- Severe ARDS carries a mortality rate exceeding 40% and significant long-term sequelae.
Purpose of the Study:
- To highlight the underdiagnosis of ARDS.
- To emphasize the severe outcomes of advanced ARDS.
- To propose preventative strategies for ARDS progression.
Main Methods:
- Review of existing literature on ARDS diagnosis and outcomes.
- Analysis of mortality and morbidity associated with severe ARDS.
- Discussion of quality improvement initiatives relevant to critical illness.
Main Results:
- ARDS is a significant contributor to respiratory failure with high mortality.
- Survivors of severe ARDS often experience lasting functional and psychological impairments.
- Current pharmacotherapies do not modify the disease course.
Conclusions:
- Preventing progression to severe ARDS is crucial.
- Quality improvement measures are essential to minimize iatrogenic harm.
- Interventions focused on reducing iatrogenic injury may improve ARDS outcomes.
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