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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
Published on: October 31, 2013
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Single molecule based SNP detection using designed DNA carriers and solid-state nanopores
Jinglin Kong1, Jinbo Zhu1, Ulrich F Keyser1
1Cavendish Laboratory, University of Cambridge, Cambridge, UK. ufk20@cam.ac.uk.
Chemical Communications (Cambridge, England)
|December 15, 2016
Abstract:
Single nucleotide polymorphisms (SNPs) play a crucial role as molecular markers in medical and diagnostic application. We demonstrate a nanopore based method for SNP detection at the single molecule level. Designed DNA carriers are used to distinguish DNA strands containing only one single base difference and follow strand displacement kinetics.
