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αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy
Yan Zhou1, Chi-Fai Chan2, Daniel W J Kwong1
1Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. wkwong@hkbu.edu.hk klwong@hkbu.edu.hk.
Chemical Communications (Cambridge, England)
|December 16, 2016
Abstract:
We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.
