Related Experiment Video

Updated: Mar 10, 2026

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

2.5K

Cholestasis in Infancy

Melissa G Andrianov, Ruba K Azzam

    Pediatric Annals
    |December 16, 2016
    PubMed

    Insights

    Jaundice in newborns requires prompt evaluation if it persists beyond two weeks. Early diagnosis of neonatal cholestasis, often caused by biliary atresia, is crucial for timely intervention and better outcomes.

    Area of Science:

    • Pediatric Gastroenterology
    • Hepatology
    • Neonatal Medicine

    Background:

    • Jaundice is a primary indicator of hepatobiliary disease across all age groups.
    • Neonatal cholestasis affects 1 in 2,500 to 5,000 live births, with biliary atresia being the most common cause.
    • Guidelines recommend evaluating infants with jaundice beyond two weeks using fractionated serum bilirubin levels.

    Purpose of the Study:

    • To discuss the etiology, diagnosis, and evaluation of cholestasis in infants.
    • To emphasize the importance of prompt diagnosis and intervention for improved clinical outcomes.

    Main Methods:

    • Review of existing literature and guidelines on neonatal cholestasis.
    • Discussion of diagnostic criteria and evaluation methods for infant jaundice.

    Main Results:

    • Jaundice is common in newborns, affecting 2.4% to 15% within the first two weeks.
    • The neonatal liver is particularly vulnerable to cholestasis.
    • Persistent jaundice beyond two weeks necessitates a fractionated serum bilirubin test.

    Conclusions:

    • Prompt evaluation, diagnosis, and intervention are vital for optimizing outcomes in infants with cholestasis.
    • Adherence to established guidelines ensures timely management of neonatal jaundice.
    • Understanding the causes and diagnostic pathways for infant cholestasis is essential for pediatric healthcare providers.

    More Related Videos

    Isolation of Neonatal Extrahepatic Cholangiocytes07:54

    Isolation of Neonatal Extrahepatic Cholangiocytes

    Published on: June 5, 2014

    10.9K
    Creation of Reversible Cholestatic Rat Model09:39

    Creation of Reversible Cholestatic Rat Model

    Published on: May 21, 2011

    15.5K

    Related Concept Videos

    Chronic Bowel Disorders: Introduction01:17

    Chronic Bowel Disorders: Introduction

    Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
    Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
    867
    Diseases of the Liver and Gallbladder01:26

    Diseases of the Liver and Gallbladder

    Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
    Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
    2.2K
    Gallbladder01:17

    Gallbladder

    The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
    The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
    2.7K
    Inborn Errors of Metabolism01:20

    Inborn Errors of Metabolism

    Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
    967
    Esophageal Varices-II: Clinical Features and Management01:28

    Esophageal Varices-II: Clinical Features and Management

    Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
    In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
    703
    Chronic Pancreatitis I: Introduction01:24

    Chronic Pancreatitis I: Introduction

    The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
    Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
    Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
    824