Pd-Catalyzed Spirocyclization via C-H Activation and Benzyne Insertion
Hyung Yoon1, Alexis Lossouarn1, Felicitas Landau1
1Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Ontario M5S 3H6, Canada.
Abstract:
A palladium-catalyzed spirocyclization forming spirooxindoles and spirodihydrobenzofurans has been achieved. Mechanistic studies suggest that the transformation proceeds through sequential carbopalladation, C-H activation, and benzyne insertion. Both classes of spirocycles have been synthesized in good to excellent yields, and the procedure is readily scalable.
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