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Updated: Mar 10, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals.

Yasmin Zakiniaeiz¹, Dustin Scheinost², Dongju Seo³

¹Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, United States.

Neuroimage. Clinical

|December 17, 2016

Summary

This summary is machine-generated.

Functional connectivity in the cingulate cortex is altered in alcohol dependence. Weaker connectivity during neutral cues and stronger connectivity to alcohol cues predict better recovery outcomes in abstinent patients.

Keywords:

Addiction Alcohol dependence Cingulate cortex Cue reactivity Functional connectivity Relapse

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Area of Science:

Neuroscience
Addiction Research
Neuroimaging

Background:

Alcohol dependence is a chronic, relapsing condition.
Alcohol and stress cues increase craving and relapse risk in recovering patients.
Functional connectivity differences in response to these cues remain understudied.

Purpose of the Study:

Investigate whole-brain functional connectivity differences in response to alcohol and stress cues.
Examine if these differences predict subsequent relapse in alcohol-dependent patients.
Compare functional connectivity between alcohol-dependent and healthy individuals.

Main Methods:

Voxel-wise functional connectivity analysis using fMRI.
Individualized imagery of alcohol, stress, and neutral cues.
Prospective 90-day relapse monitoring and Cox proportional hazard regression.

Main Results:

Alcohol-dependent patients showed blunted cingulate cortex connectivity to stress and alcohol cues compared to neutral cues.
Weaker anterior and mid-cingulate cortex connectivity during neutral cues predicted longer time to relapse.
Greater posterior cingulate cortex connectivity to alcohol vs. stress cues also predicted better recovery.

Conclusions:

The cingulate cortex is crucial in disrupted functional connectivity during cue processing in alcohol dependence.
Cingulate cortex connectivity patterns serve as a marker for predicting alcohol relapse.
Data-driven functional connectivity analysis reveals key neural mechanisms in alcohol relapse.