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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Ester-Based Hydrophilic Cyclodextrin Nanosponges for Topical Ocular Drug Delivery
Zikhona Hayiyana, Yahya E Choonara, Aubrey Makgotloe
1Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
Current Pharmaceutical Design
|December 17, 2016
Summary
Cyclodextrin nanosponges enhance drug delivery for eye applications by improving solubility and corneal permeation. These novel drug carriers show significant potential for topical ocular drug delivery systems.
Area of Science:
- Supramolecular chemistry
- Materials science
- Pharmaceutical sciences
Background:
- Cyclodextrin-based nanosponges are hyper-cross-linked supramolecular architectures.
- They form inclusion and non-inclusion complexes with various molecules, enhancing stability, solubility, and membrane permeability.
- Unlike parent cyclodextrins, nanosponges accommodate both hydrophobic and hydrophilic compounds.
Purpose of the Study:
- To assess the potential of ester-based hydrophilic nanosponges as drug carriers for topical ocular drug delivery.
- To evaluate drug loading, drug release, phase solubility, and ex vivo corneal permeation.
- To determine the efficacy of nanosponges in improving drug delivery to the eye.
Main Methods:
- Synthesis of ester-based cyclodextrin-based nanosponges via cross-linking beta-cyclodextrin with pyromellitic dianhydride.
- Optimization of cross-linker concentration for drug loading capacity.
- Analysis of drug release kinetics, solubility, and permeation effects using varying drug-to-nanosponge ratios.
Main Results:
- Formulation of a cyclodextrin-based nanosponge system demonstrating improved corneal permeation and drug solubility.
- Achieved up to 75% drug permeation with nanosponges, compared to 28% for the pure drug.
- Nanosponges provided approximately one hour of drug release due to high solubility in aqueous media.
Conclusions:
- Ester-based hydrophilic cyclodextrin-based nanosponges are effective drug delivery systems for topical ocular applications.
- These nanosponges improve drug stability, solubility, and corneal permeation.
- The study highlights the potential of nanosponges for enhanced ocular drug delivery.
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