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Related Experiment Video

Updated: Mar 9, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

Novel Lymphatic Imaging Techniques.

¹Division of Cardiology, HUP/CHOP Center for Lymphatic Imaging and Interventions, Children's Hospital of Philadelphia, Philadelphia, PA.

Techniques in Vascular and Interventional Radiology

|December 21, 2016

Summary

This summary is machine-generated.

New noninvasive imaging techniques like MR lymphangiography improve visualization of lymphatic system anatomy and flow. This advances understanding and treatment of lymphatic flow disorders.

Keywords:

Dynamic contrast MR lymphangiography Lymphangiography Lymphatic flow disorders Lymphatic leaks Pulmonary lymphatic perfusion syndrome

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Last Updated: Mar 9, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

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Published on: August 9, 2019

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

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Published on: May 22, 2020

Area of Science:

Physiology
Medical Imaging
Immunology

Background:

The lymphatic system is crucial for immune function, metabolite transport, and fluid balance, returning tissue fluid to the venous system.
Historically, a lack of noninvasive imaging methods has hindered understanding of lymphatic flow pathophysiology and treatment of related disorders.

Purpose of the Study:

To highlight recent advancements in lymphatic imaging and their impact on understanding and treating lymphatic flow disorders.
To discuss the clinical utility of novel noninvasive imaging techniques for lymphatic system visualization.

Main Methods:

Development and application of noncontrast magnetic resonance (MR) lymphangiogram and dynamic contrast MR lymphangiography for visualizing central lymphatic anatomy and flow dynamics.
Utilization of intranodal lymphangiogram as a primary interventional modality for accessing central lymphatic ducts.

Main Results:

Dynamic contrast MR lymphangiography offers high spatial and temporal resolution, providing insights into pulmonary lymphatic flow disorders.
Intranodal lymphangiogram has become the standard for lymphatic interventions, offering efficient and reliable access to central lymphatic ducts.

Conclusions:

Recent advancements in MR lymphangiography and intranodal lymphangiogram have significantly improved the ability to diagnose and manage lymphatic flow disorders.
These new imaging and interventional techniques are revitalizing research and treatment development for the lymphatic system.