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Spiro Meroterpenoids from Ganoderma applanatum.

Qi Luo1,2, Xiao-Yi Wei3, Jing Yang1

  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204, People's Republic of China.

Journal of Natural Products
|December 21, 2016
PubMed
Summary
This summary is machine-generated.

New spiro meroterpenoids were isolated from the fungus Ganoderma applanatum. Compounds 7 and 8 showed inhibitory activity against JAK3 kinase, indicating potential therapeutic applications.

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Area of Science:

  • Natural Products Chemistry
  • Medicinal Chemistry
  • Mycology

Background:

  • The fungus Ganoderma applanatum is a source of bioactive natural products.
  • Spiro meroterpenoids represent a complex class of fungal metabolites with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new spiro meroterpenoids from Ganoderma applanatum.
  • To investigate the potential of these compounds as inhibitors of JAK3 kinase.

Main Methods:

  • Isolation and purification of compounds using chromatographic techniques.
  • Structure elucidation employing spectroscopic methods (NMR, MS) and X-ray crystallography.
  • In vitro biological assays to determine JAK3 kinase inhibitory activity.

Main Results:

  • Isolation of seventeen spiro meroterpenoids, including twelve new compounds (Spiroapplanatins A-Q).
  • Determination of absolute configurations using ECD and 13C NMR calculations, and single-crystal X-ray diffraction.
  • Compounds 7 and 8 exhibited JAK3 kinase inhibition with IC50 values of 7.0 ± 3.2 μM and 34.8 ± 21.1 μM, respectively.

Conclusions:

  • The study identified novel spiro meroterpenoids from Ganoderma applanatum.
  • Compounds 7 and 8 demonstrate promising JAK3 kinase inhibitory activity, warranting further investigation for drug development.