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A 6/5/6/5-Fused Indeno[7,1-bc]furan Diterpenoid Skeleton from Pinus yunnanensis Resins with Anti-Neuroinflammatory
Jing Liu1, Wei-Fen Li1, Shao-Jin Luo1
1Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Marshall Laboratory of Biomedical Engineering, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, P. R. China.
Abstract:
Pinynditerpene A (1), an unprecedented abietane diterpenoid featuring a unique 6/5/6/5-fused indeno[7,1-bc]furan skeleton with 5 consecutive chiral centers, was isolated from Pinus yunnanensis resins. Its structure was elucidated by spectroscopic, computational, and crystallographic methods. 1 was found to be able to alleviate inflammation associated depression-like behaviors in mice, exerting its significance in mood disorders.
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