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Updated: Sep 9, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum
Yun-Yun Liu1, Wei-Fen Li1, Yong-Sheng Xu1
1Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, P. R. China.
Abstract:
Chizhiaroterpenoids A-C (1-3), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (1), 6/6/6/6/7 (2), and 6/6/6/5/6 (3) ring systems, were isolated from Ganoderma lucidum. Their biosynthetic pathways were proposed. 1 and 3 suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice. Additionally, 2 and 3 inhibited cancer-associated fibroblast-mediated extracellular matrix remodeling by modulating laminin, suggesting potential anti-breast cancer effects.
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