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Updated: Sep 9, 2025
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum
Yun-Yun Liu1, Wei-Fen Li1, Yong-Sheng Xu1
1Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, P. R. China.
Organic Letters
|September 3, 2025
Summary
Three new triterpenoids from Ganoderma lucidum show anti-inflammatory and anti-depression effects. Compounds also demonstrated potential in inhibiting breast cancer progression by modulating extracellular matrix remodeling.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Molecular Biology
Background:
- Ganoderma lucidum is a medicinal mushroom with a rich history in traditional medicine.
- Triterpenoids are a diverse class of natural compounds known for their wide range of biological activities.
- Exploring novel compounds from natural sources is crucial for drug discovery.
Purpose of the Study:
- To isolate and characterize new triterpenoids from Ganoderma lucidum.
- To investigate the anti-inflammatory and anti-depression potential of isolated compounds.
- To evaluate the effects of compounds on cancer-associated fibroblast-mediated extracellular matrix remodeling.
Main Methods:
- Isolation and structure elucidation of compounds using spectroscopic techniques.
- In vitro assays to assess anti-inflammatory effects on BV2 cells.
- In vivo studies to evaluate depression-like behaviors in mice.
- Analysis of extracellular matrix remodeling in cancer-associated fibroblasts.
Main Results:
- Three novel benzofused lanostane-type triterpenoids, Chizhiaroterpenoids A-C (1-3), were identified.
- Compounds 1 and 3 exhibited anti-inflammatory properties by suppressing lipopolysaccharide-induced inflammation and restoring BDNF levels.
- Compounds 2 and 3 inhibited extracellular matrix remodeling by modulating laminin, suggesting anti-breast cancer activity.
Conclusions:
- Chizhiaroterpenoids A-C represent a new class of triterpenoids with unique skeletal structures.
- Compounds 1 and 3 possess therapeutic potential for inflammatory conditions and depression.
- Compounds 2 and 3 show promise as agents to combat breast cancer progression through ECM remodeling inhibition.
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