Know your neighbors: Different tumor microenvironments have implications in immunotherapeutic targeting strategies

Christina D Pham1, Duane A Mitchell1

  • 1Preston A. Wells, Jr. Center for Brain Tumor Therapy, Department of Neurosurgery, University of Florida , Gainesville, FL, USA.

Oncoimmunology
|December 22, 2016
PubMed

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The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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