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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

[Importance of associated microorganisms in the development of acute pneumonia]

G P Kondratenko, L Z Gritsenko, V B Gnilitskaia

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |June 1, 1989
    PubMed

    Insights

    Pneumonia is often caused by microbial associations, with pneumococci being most common. Understanding these microbial patterns aids in effective treatment and prognosis for acute pneumonia.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pulmonology

    Context:

    • Acute pneumonia affects numerous patients globally.
    • Accurate etiological diagnosis is crucial for effective treatment.
    • Microbial factors significantly influence disease presentation and progression.

    Purpose:

    • To investigate the role of microbial associations in acute pneumonia.
    • To identify prevalent microorganisms and their combinations.
    • To correlate microbial findings with clinical manifestations.

    Summary:

    • Quantitative microbiological analysis of sputum from 106 acute pneumonia patients.
    • Identified microbial associations in 67.9% of cases, with pneumococci being predominant.
    • Observed specific microbial combinations (2-3 species at high concentrations) in 59.7% of patients.
    • Found correlations between microbial presence and clinical disease presentation.

    Impact:

    • Provides insights into the etiological structure of acute pneumonia.
    • Supports the development of targeted etiotropic therapy.
    • Facilitates accurate prognostication of disease outcomes.
    • Enables dynamic monitoring of respiratory tract microflora and therapy effectiveness.

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