Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plastic Nanofluidic Sensor with a Solid-Phase Bioreactor and Dual Nanopore Reader: Studying Biological Reactions at the Single-Molecule Level.

ACS applied materials & interfaces·2026
Same author

Microfluidics for Blood Disorders and Hematological Disease Monitoring and Modeling.

International journal of molecular sciences·2026
Same author

The evolution of nanopore measurements: from biological out-of-plane pores to plastic in-plane pores.

Lab on a chip·2026
Same author

Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis.

ACS nano·2025
Same author

Insights on using plastic-based dual in-plane nanopore sensors for differentiation and shape determinations of single protein molecules.

Scientific reports·2025
Same author

Characterizing Recent PDMS Changes in Electrokinetic-Based Microfluidic Devices' Performance and Manufacturing for Cell Sorting Applications.

Electrophoresis·2025

Related Experiment Video

Updated: Mar 9, 2026

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
09:54

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

8.1K

Thermoplastic nanofluidic devices for biomedical applications.

Kumuditha M Weerakoon-Ratnayake1, Colleen E O'Neil2, Franklin I Uba3

  • 1Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA and NIH Biotechnology Resource Center of Biomodular Multiscale Systems for Precision Medicine, USA.

Lab on a Chip
|December 24, 2016
PubMed
Summary

High-volume, low-cost nanofluidic devices with sub-150 nm dimensions are enabling commercial applications in biomolecular analysis. Recent advancements in fabrication and characterization are key to this translation.

More Related Videos

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
11:13

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

11.3K
Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

9.4K

Related Experiment Videos

Last Updated: Mar 9, 2026

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
09:54

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

8.1K
Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
11:13

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

11.3K
Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

9.4K

Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Microfluidics is transitioning from basic research to commercial applications, particularly in healthcare.
  • High-throughput microfabrication methods like thermal embossing and injection molding are crucial for low-cost microfluidic consumables.
  • Nanofluidics presents unique capabilities for biomolecular analysis beyond the microscale.

Purpose of the Study:

  • To review recent advancements in thermoplastic nanofluidic device fabrication, assembly, surface modification, and characterization.
  • To highlight the commercialization potential of nanofluidics through high-production, low-cost manufacturing.
  • To showcase applications of nanoscale phenomena in biomolecular analysis using nanofluidic devices.

Main Methods:

  • Review of recent literature on nanofluidic device fabrication techniques.
  • Discussion of assembly and surface modification strategies for thermoplastic nanofluidics.
  • Analysis of characterization methods for sub-150 nm nanofluidic devices.

Main Results:

  • Functional thermoplastic nanofluidic devices with sub-150 nm dimensions have been successfully fabricated.
  • High process yield rates are achievable, facilitating the commercial translation of nanofluidics.
  • Nanoscale phenomena offer novel approaches for biomolecular analysis.

Conclusions:

  • High-production, low-cost nanofluidic devices are essential for commercialization.
  • Recent advancements enable the development of thermoplastic nanofluidic devices for biomolecular analysis.
  • Future outlooks focus on exploiting nanoscale phenomena for advanced analytical applications.