[Possibility of predicting and preventing psychotic disorders during ketamine anesthesia]

The results of ketamine anesthesia are analyzed in 327 patients after stomach resection and cholecystectomy. Preoperative determination of nervous system type, using MMPI test, has revealed maximum incidence of psychotic disorders after ketamine anesthesia in anosognosia syndrome and paranoia. Administration of a neurometabolic stimulator nootropil (pyracetam) prior to extubation in 143 patients decreased the incidence of psychotic disorders from 23.3% to 3.5%, which was confirmed by the results of psychophysiological tests. It is concluded that ketamine anesthesia is inadvisable in patients with anosognosia syndrome and paranoia. To prevent psychotic disorders it is recommended to administer nootropil that recovers intra- and inter-hemisphere connections in the brain.