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MicroRNAs in the Occurrence and Development of Primary Hepatocellular Carcinoma
Jie Xu1, Ji Li2, Tai-Hao Zheng3
1Department of Gastrointestinal Surgery, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
Abstract:
Hepatocellular carcinoma is one of the deadliest types of cancer. Despite improvements in treatment over the past few decades, patient survival remains poor and there is an urgent need for development of targeted therapies. MicroRNAs represent a class of small RNAs, frequently deregulated in human malignancies. We are reviewing the role of microRNA in the development of primary hepatocellular carcinoma and its use as a biomarker for early diagnosis and clinical treatment. First, we describe the current incidence and possible causes of the incidence of hepatocellular carcinoma, followed by the introduction of microRNA synthesis, maturation and function, and finally we explain the role of microRNA in the development of hepatocellular carcinoma and its clinical value as a biological marker in the diagnosis and treatment of liver cancer. A comprehensive analysis of cellular microRNA is a benefit for early diagnosis of hepatocellular carcinoma and early clinical intervention, and microRNA is considered by some to be a key target of gene therapy to control the occurrence and development of hepatocellular carcinoma..
Insights
MicroRNAs are small RNAs often altered in cancer. This review explores their role in hepatocellular carcinoma development and potential as biomarkers for early diagnosis and targeted liver cancer therapy.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Hepatocellular carcinoma (HCC) remains a leading cause of cancer death with poor patient survival despite treatment advances.
- MicroRNAs (miRNAs), small non-coding RNAs, are frequently dysregulated in various human cancers, including HCC.
- There is a critical need for novel targeted therapies and reliable biomarkers for HCC management.
Purpose of the Study:
- To review the role of microRNAs in the pathogenesis of primary hepatocellular carcinoma.
- To evaluate the clinical utility of microRNAs as biomarkers for early diagnosis and treatment of liver cancer.
- To discuss the potential of microRNAs as therapeutic targets for HCC.
Main Methods:
- Literature review focusing on microRNA synthesis, maturation, function, and their involvement in HCC.
- Analysis of current incidence and etiological factors of hepatocellular carcinoma.
- Examination of the clinical value of microRNAs in HCC diagnosis and treatment.
Main Results:
- MicroRNAs are significantly deregulated during hepatocellular carcinoma development.
- Altered microRNA profiles are associated with HCC progression and patient outcomes.
- MicroRNAs show promise as sensitive biomarkers for early HCC detection.
Conclusions:
- Comprehensive analysis of cellular microRNAs aids in early HCC diagnosis and clinical intervention.
- MicroRNAs represent a promising avenue for targeted gene therapy in controlling HCC occurrence and development.
- Targeting microRNAs could offer a new strategy for improving hepatocellular carcinoma treatment outcomes.
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