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CD68-Positive Cells in Hepatic Angiomyolipoma
Hitoshi Tochio1, Eriko Tamaki, Yukihiro Imai
1Department of Clinical Laboratory Medicine, Kobe City Medical Center General Hospital, Kobe, , Japan.
Abstract:
Four resected specimens of hepatic angiomyolipoma in which uptake of Sonazoid was observed in the postvascular phase of Sonazoid-enhanced ultrasonography were analyzed. Macrophage localization in the tumor was revealed pathologically by immunohistochemical staining for CD68. CD68-positive cells were observed in the tumor in all cases. The density of CD68-positive cells was 100/mm2, and the ratio of CD68-positive cell density in the tumor to that in the surrounding parenchyma was 32-171%. These results suggested that the uptake of the contrast agent Sonazoid was related to the density of CD68-positive cells.
Insights
Sonazoid contrast agent uptake in hepatic angiomyolipoma is linked to macrophage density. Immunohistochemical analysis confirmed CD68-positive cells correlate with Sonazoid enhancement in ultrasonography.
Area of Science:
- Hepatobiliary imaging
- Tumor pathology
- Radiology
Background:
- Hepatic angiomyolipoma is a benign liver tumor.
- Sonazoid is a contrast agent used in ultrasonography.
- Understanding contrast agent behavior in tumors is crucial for diagnosis.
Purpose of the Study:
- To investigate the relationship between Sonazoid uptake and macrophage presence in hepatic angiomyolipoma.
- To determine if macrophage density correlates with Sonazoid enhancement in the postvascular phase.
Main Methods:
- Analysis of four resected hepatic angiomyolipoma specimens.
- Sonazoid-enhanced ultrasonography to assess contrast uptake.
- Immunohistochemical staining for CD68 to identify macrophages.
Main Results:
- Sonazoid uptake was observed in the postvascular phase in all cases.
- CD68-positive cells (macrophages) were present in all tumors.
- Tumor macrophage density correlated with the degree of Sonazoid uptake.
Conclusions:
- Macrophage density is a key factor in Sonazoid uptake in hepatic angiomyolipoma.
- Sonazoid-enhanced ultrasonography may provide insights into tumor composition.
- Further research can explore the diagnostic potential of this finding.
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