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Does the MTHFR A1298C Polymorphism Modulate the Cardiorespiratory Response to Training?
Paweł Cięszczyk1, Aleksandra Zarębska2, Zbigniew Jastrzębski2
1University of Szczecin, Faculty of Physical Education and Health Promotion, Szczecin, Poland.
Journal of Human Kinetics
|December 30, 2016
Summary
The MTHFR A1298C gene variant influences exercise response. Women with CC+AC genotypes showed greater VO2max improvements after aerobic training compared to AA genotypes.
Area of Science:
- Exercise Physiology
- Human Genetics
- Nutrigenetics
Background:
- Individual responses to exercise training vary significantly.
- The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism is investigated for its role in trainability.
- Understanding genetic influences on exercise response can optimize training protocols.
Purpose of the Study:
- To investigate the impact of the MTHFR A1298C polymorphism on aerobic and anaerobic performance.
- To assess the influence of this polymorphism on body composition changes following exercise.
- To determine if MTHFR genotype affects trainability in young women.
Main Methods:
- A cohort of 201 young Polish women (aged 21±1 years) participated.
- Participants underwent a 12-week low-to-high impact aerobic exercise program.
- Measurements included somatic features, aerobic capacity (VO2max), cardiorespiratory indices, and anaerobic power before and after training. Statistical analysis used mixed 2x2 ANOVA.
Main Results:
- No significant genotype-training interactions were found for body mass or composition.
- Significant genotype-training interactions were observed for maximal oxygen uptake (VO2max), maximal heart rate (HRmax), and the ratio of heart rate at anaerobic threshold to maximal heart rate (HRAT/HRmax).
- The CC+AC genotype group demonstrated significantly greater improvements in VO2max compared to the AA genotype group.
Conclusions:
- Genetic factors, specifically the MTHFR A1298C polymorphism, contribute to individual differences in exercise trainability.
- The MTHFR A1298C variant appears to influence aerobic capacity adaptations to exercise training.
- This polymorphism is one of several genetic factors influencing response to exercise interventions.
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