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Ultra-slow N-Acetyltransferase 2 Is Associated with Recurrence-free Time in Bladder Cancer Patients

Silvia Selinski1, Holger Gerullis2, Thomas Otto3

  • 1Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany.

European Urology
|January 2, 2017
PubMed
Abstract

No abstract available in PubMed .

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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