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Oromucosal multilayer films for tailor-made, controlled drug delivery
Sandra Lindert1, Jörg Breitkreutz1
1a Institute of Pharmaceutics and Biopharmaceutics , Heinrich Heine University Düsseldorf , Düsseldorf , Germany.
Expert Opinion on Drug Delivery
|January 4, 2017
Summary
Oromucosal multilayer films offer a promising approach for controlled drug delivery via the oral mucosa. While flexible in design for various conditions, standardized quality testing methods are needed.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Oral Mucosa Applications
Background:
- The oral mucosa is gaining importance as an alternative route for controlled drug delivery.
- Oromucosal multilayer films, as defined in the Ph.Eur., represent a promising dosage form for this route.
- The development of high molecular weight drugs necessitates advanced delivery technologies.
Purpose of the Study:
- To provide an overview of multilayer films as drug delivery tools.
- To discuss manufacturing processes and characterization methods for oromucosal multilayer films.
- To classify published data on multilayer films for oromucosal use, including indications and active pharmaceutical ingredients (APIs).
Main Methods:
- Review of existing literature on oromucosal multilayer films.
- Analysis of manufacturing processes and characterization techniques.
- Classification of films based on therapeutic areas and incorporated APIs.
Main Results:
- Multilayer films are suitable for tailor-made, controlled delivery of APIs to or through oral surfaces.
- Flexible layer design addresses needs in areas like hormonal disorders, cardiovascular diseases, and infection treatment.
- A lack of discriminating or standardized testing methods for assessing film quality was identified.
Conclusions:
- Oromucosal multilayer films are a flexible and promising option for advanced drug delivery.
- Further development of standardized testing methods is crucial for reliable quality assessment.
- The technology is well-suited for delivering high molecular weight drugs for various indications.
Keywords:
Mucoadhesive filmsbilayer filmsbuccal formulationsmultilayer filmsoromucosal permeationsublingual formulationsMore Related Videos
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