[Association between 5-hydroxytryptamine 2A receptor gene polymorphisms and susceptibility to occupational stress in...

Objective: To investigate the association between 5-hydroxytryptamine 2A (5-HT2A) receptor gene polymorphisms and occupational stress in oilfield workers. Methods: Cluster sampling was used to select 826 oilfield workers from January to August, 2013. The SNaPshot single nucleotide polymorphism (SNP) genotyping method was used to determine the genotypes of rs6313, rs1923884, and rs2070040 in 5-HT2A receptor gene, and the Occupational Stress Inventory-Revised Edition was used to analyze occupational stress in these workers. Results: There were no significant differences in occupational stress between groups with different individual characteristics (P>0.05 ) . As for the comparison of occupational stress scores between workers with different genotypes of each SNP of 5-HT2A receptor gene, the workers with CC and CT genotypes of rs6313 had significantly higher role boundary scores than those with TT genotype (P<0.05) , and the workers with CC genotype had a significantly higher vocational stress score than those with CT genotype (P<0.05) ; the workers with CT genotype of rs1923884 had a significantly higher occupational role score than those with CC genotype (P<0.05) and a significantly higher coping resources score than those with CC and TT genotypes (P<0.05) ; the workers with AG genotype of rs2070040 had a significantly higher vocational stress score than those with AA genotype (P<0.05) . The ordinal multinomial logistic regression analysis showed that workers with CT genotype of rs1923884 were susceptible to occupational stress (OR=1.56, 95%CI 1.10~2.20) . Conclusion: CT genotype of rs1923884 in 5-HT2A receptor gene may be associated with the susceptibility to occupational stress in oilfield workers.