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Updated: Mar 9, 2026

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

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Published on: October 20, 2010

Oncologic Procedures Amenable to Fluorescence-guided Surgery.

Kiranya E Tipirneni¹, Jason M Warram, Lindsay S Moore

¹*Department of Surgery, University of Alabama at Birmingham, Birmingham, AL †Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL ‡School of Medicine, University of Alabama at Birmingham, Birmingham, AL §School of Medicine, University Medical Center Groningen, Groningen, The Netherlands ¶Department of Surgery, Stanford University, Stanford, CA ||Department of Urology, Stanford University, Stanford, CA **Division of Surgical Oncology, Department of Surgery, University of California San Diego, La Jolla, CA ††Division of Orthopedic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL ‡‡Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands §§Department of Radiology, University of Alabama at Birmingham, Birmingham, AL ¶¶Department of Otolaryngology, Stanford University, Stanford, CA.

Annals of Surgery

|January 4, 2017

Summary

This summary is machine-generated.

Fluorescence-guided surgery (FGS) enhances cancer resection by detecting hidden disease, potentially improving patient survival and quality of life. This review explores FGS applications in surgical oncology and optimal trial endpoints for various tumor types.

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Area of Science:

Surgical Oncology
Medical Imaging
Cancer Research

Background:

Surgical resection is key for cancer treatment, aiming for negative margins to improve survival.
Historically, margin positivity rates remain high, leading to re-excision and overtreatment.
Fluorescence-guided surgery (FGS) offers a solution by enabling visualization of subclinical disease.

Purpose of the Study:

To review the potential of fluorescence imaging in surgical oncology.
To identify patient populations that may benefit most from FGS.
To explore optimal trial endpoints for FGS in different tumor types.

Main Methods:

Systematic review of clinical trials.gov.
Search terms included "fluorescence," "image-guided surgery," and "near-infrared imaging."
Included trials utilizing FGS for primary tumor resection up to May 2016.

Main Results:

The search identified 68 relevant clinical trials.
FGS was primarily applied in three resection methods: debulking, wide local excision, and whole-organ excision.
The review focused on FGS for tumor debulking, wide local excision, and whole-organ resection.

Conclusions:

FGS has the potential to improve patient survival and quality of life.
The increasing number of clinical trials indicates broad applicability of FGS.
Further research is needed to define optimal FGS use and endpoints for specific cancers.