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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
The profile of Cyr61 expression data correlate to the skin inflammation in psoriasis
Pinru Wu1, Gang Ma2, Ningli Li3
1Shanghai Institute of Immunology, Institute of Medical science, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Dermatology, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract:
The data presented in this article are related to the research article entitled "Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway" (Pinru Wu, Gang Ma, Xianjin Zhu, Ting Gu, Jie Zhang, Yue Sun, Hui Xu, Rongfen Huo, Beiqing Wang, Baihua Shen, Xiangdong Chen, Ningli Li, 2016) [1]. Cysteine-rich 61 (Cyr61/CCN1), a secreted extracellular matrix protein, is a novel proinflammatory factor. In this dataset skin samples from normal donors and psoriasis vulgaris patients were examined the expression of Cyr61 and IL-8 using immunohistochemistry. IMQ-induced psoriasis-like mice were treated with anti-Cyr61monoclonal antibodies (mAb).
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