Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emergence of a mixed CAF population by FAP-CD3 T-cell engager limits therapeutic efficacy.

Journal for immunotherapy of cancer·2026

Same author

EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi-Omics and Experimental Study.

Clinical and translational science·2026

Same author

Atmospheric bulk deposition of microplastics in Jiuzhaigou World Natural Heritage Site: Tourism-associated divergence between particle number and polymer mass fluxes.

Journal of hazardous materials·2026

Same author

Application of ultrasound and methylation omics detection in the diagnosis of endometrial cancer.

Frontiers in oncology·2026

Same author

Spatially confined multi-enzyme cascade nanoreactor for portable and real-time pesticide detection.

Journal of nanobiotechnology·2026

Same author

Comparative Evaluation of Packing Models for Mix Design and Performance Optimization of Ceramsite-Modified Lightweight Ultra-High-Performance Concrete.

Materials (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Immune adaptation to chronic intense exercise training: new microarray evidence.

Dongmei Liu¹, Ru Wang¹, Ana R Grant²

¹School of Kinesiology, Shanghai University of Sport, Qinyuanhuan Road, #650, Yangpu District, Shanghai, China.

|January 7, 2017

Summary

This summary is machine-generated.

High-intensity endurance exercise alters gene expression in athletes' blood cells, boosting protein production and mitochondrial function while reducing inflammation. This suggests peripheral blood reflects systemic exercise effects.

Keywords:

Athletes High-intensity endurance training Immunity Leukocytes Transcriptome

More Related Videos

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Related Experiment Videos

Last Updated: Mar 9, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Area of Science:

Exercise immunology
Molecular biology
Genomics

Background:

Endurance exercise, particularly high-intensity training, significantly impacts the immune system.
The precise mechanisms behind exercise's immune-regulatory effects are not fully understood.
Investigating transcriptional profiles in athletes provides insight into these mechanisms.

Purpose of the Study:

To explore changes in the transcriptional profile of blood leukocytes in young endurance athletes.
To compare these profiles with those of healthy, sedentary individuals.
To elucidate the molecular underpinnings of exercise-induced immune modulation.

Main Methods:

Utilized Affymetrix human gene 1.1 ST array for transcriptional profiling.
Analyzed transcriptome differences using Intensity-based Hierarchical Bayes method.
Employed Logistic Regression-based gene set enrichment analysis to identify affected pathways.

Main Results:

Identified 72 differentially expressed transcripts in athletes' leukocytes (False Discovery Rate < 0.05).
Upregulated genes were primarily involved in ribosomal protein production and mitochondrial oxidative phosphorylation.
Downregulated genes were associated with inflammation and immune activity.

Conclusions:

Intense endurance training induces chronic transcriptional changes in peripheral blood leukocytes.
These changes include upregulation of protein production/mitochondrial energetics and downregulation of inflammatory genes.
Peripheral blood serves as a valid surrogate tissue for studying systemic exercise training effects.