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Promoting bioengineered tooth innervation using nanostructured and hybrid scaffolds.

S Kuchler-Bopp1, A Larrea2, L Petry1

  • 1INSERM, UMR 1109, Osteoarticular and Dental Regenerative NanoMedicine Laboratory, FMTS, 11 rue Humann, Strasbourg, Strasbourg, France(1); Université de Strasbourg, Faculté de Chirurgie Dentaire, 1 place de l'Hôpital, Strasbourg F-67000, France.

Acta Biomaterialia
|January 7, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed Cyclosporine A (CsA)-loaded nanoparticles embedded in PCL scaffolds to enhance bioengineered tooth innervation. This approach successfully promoted nerve regeneration in dental implants, showing significant potential for dental engineering applications.

Keywords:
Bioengineered toothCyclosporine AElectrospun polycaprolactoneInnervationNanoparticles

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Tooth innervation, mediated by trigeminal ganglia, is crucial for dental function and protection.
  • Cyclosporine A (CsA) accelerates tissue innervation, including bioengineered teeth, but systemic administration has side effects.

Purpose of the Study:

  • To develop CsA-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles embedded in polycaprolactone (PCL) scaffolds for enhanced bioengineered tooth innervation.
  • To evaluate the efficacy of these functionalized scaffolds in promoting nerve regeneration in vivo.

Main Methods:

  • Preparation of CsA-loaded PLGA nanoparticles and their incorporation into electrospun PCL scaffolds.
  • Co-implantation of dental re-associations with trigeminal ganglia on functionalized scaffolds in adult ICR mice.
  • Histological analysis, indirect immunofluorescence, and transmission electron microscopy (TEM) to assess tooth development and innervation.

Main Results:

  • The PCL scaffolds did not adversely affect tooth development post-implantation.
  • Scaffolds functionalized with CsA-loaded PLGA nanoparticles resulted in 88.4% of regenerated teeth being innervated.
  • Successful local, sustained delivery of CsA was achieved, promoting nerve regeneration.

Conclusions:

  • Functionalized PCL scaffolds with CsA-loaded nanoparticles represent a promising strategy for enhancing bioengineered tooth innervation.
  • This approach offers a potential solution to avoid systemic CsA side effects while promoting neural regeneration for dental applications.