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Updated: Mar 9, 2026
04:40
Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes
Published on: July 7, 2023
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Toward biocompatible dinitrosyl iron complexes: sugar-appended thiolates.
Randara Pulukkody1, Rachel B Chupik1, Steven K Montalvo1
1Department of Chemistry, Texas A & M University, College Station, TX 77843, USA. marcetta@chem.tamu.edu.
Chemical Communications (Cambridge, England)
|January 7, 2017
Summary
Monomeric and dimeric tetraacetylglucose iron complexes were studied for nitric oxide (NO) release. These dinitrosyl iron complexes (DNICs) released NO when exposed to chemical traps and endothelial cells.
Area of Science:
- Biochemistry
- Materials Science
- Cell Biology
Background:
- Dinitrosyl iron complexes (DNICs) are known to release nitric oxide (NO).
- Tetraacetylglucose ligands can modify the properties of metal complexes.
- Understanding NO release mechanisms is crucial for therapeutic applications.
Purpose of the Study:
- To synthesize and characterize monomeric and dimeric tetraacetylglucose-containing dinitrosyl iron complexes (DNICs).
- To investigate the nitric oxide (NO) release profile of these DNICs.
- To assess NO release in the presence of both chemical NO-trapping agents and biological systems (endothelial cells).
Main Methods:
- Synthesis of monomeric and dimeric tetraacetylglucose-DNICs.
- Characterization of the synthesized complexes.
- In vitro studies using chemical NO-trapping agents.
- Co-culture experiments with endothelial cells to monitor NO release.
Main Results:
- Successful preparation of both monomeric and dimeric tetraacetylglucose-DNICs.
- Demonstrated NO release from the DNICs under experimental conditions.
- Evidence of NO release in the presence of endothelial cells, indicating biological relevance.
Conclusions:
- Tetraacetylglucose-containing DNICs are capable of releasing nitric oxide.
- The release of NO by these complexes is observable in both chemical and biological contexts.
- These findings contribute to the understanding of DNIC chemistry and their potential biological activity.
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