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Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Published on: June 6, 2018
Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
Hyong Woo Moon1, Jung Woo Park1, Kyu Won Lee1
1Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Purpose:
This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats.
Materials And Methods:
Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.
Results:
Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.
Conclusions:
Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
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