A new indole alkaloid with anti-inflammatory activity from Nauclea officinalis
Qing-Long Liu1,2, A-Hong Chen1,2, Jin-Ying Tang1,2
1a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.
Abstract:
A new indole alkaloid, 17-O-methyl-19-(Z)-naucline (1), together with seven known alkaloids (2-8), were isolated from the stems and leaves of Nauclea officinalis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literature. 17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50 value of 3.6 μM.
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