A new monoterpenoid indole alkaloid from Ochrosia elliptica
A-Hong Chen1,2, Qing-Long Liu1,2, Yan-Lei Ma1,2
1a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.
Abstract:
A new monoterpenoid indole alkaloid, 10-methoxyakuammidine (1), together with four known alkaloids (2-5), were isolated from the stems and leaves of Ochrosia elliptica. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. 1 exhibited inhibitory effects with IC50 values comparable to those of cisplatin.
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