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[Buschke-Lowenstein tumors].
1Anästhesiologie und operative Intensivmedizin, Luisenhospital Aachen, Boxgraben 99, 52064, Aachen, Deutschland.
Buschke-Lowenstein tumors (BLT) are low-grade epithelial cancers evolving from condylomata acuminata, often linked to human papillomavirus (HPV). Organ preservation surgery is recommended for treatment, even with focal invasion.
Area of Science:
- Dermatology
- Oncology
- Virology
Background:
- Buschke-Lowenstein tumor (BLT) is a giant condyloma acuminatum characterized by destructive growth without invasion.
- BLT is considered a low-grade in situ epithelial cancer that develops from condylomata acuminata.
Purpose of the Study:
- To classify Buschke-Lowenstein tumors (BLT).
- To provide therapeutic guidelines for BLT management.
Main Methods:
- A MEDLINE literature search was conducted from 2006 to 2016.
- Diagnosis is confirmed by human papillomavirus (HPV) detection and histology.
- CT scans are used to assess for deeper invasion.
Main Results:
- Low-risk mucosotropic HPV infection differentiates BLT from verrucous carcinoma.
- Over 100 new cases were reported in the last decade.
- Focal invasion occurred in 12% of cases, and HIV infection was noted in 14%.
Conclusions:
- Buschke-Lowenstein tumors are low-grade in situ carcinomas originating from condylomata acuminata.
- Despite frequent focal invasion, metastases are rare.
- Organ preservation surgery is the recommended therapeutic approach.
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