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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Heart Failure Due to Reduced Ejection Fraction: Medical Management
William E Chavey1, Robrt V Hogikyan1, R Van Harrison1
1University of Michigan Health System, Ann Arbor, MI, USA.
American Family Physician
|January 12, 2017
Summary
Effective heart failure treatment involves several medication classes, including ACE inhibitors and beta blockers, alongside devices like defibrillators. Disease management programs and telemonitoring further reduce hospitalizations and mortality in heart failure patients.
Area of Science:
- Cardiology
- Pharmacology
- Medical Devices
Background:
- Heart failure is a prevalent condition with significant morbidity and mortality.
- Effective management strategies are crucial for improving patient outcomes.
Purpose of the Study:
- To summarize evidence-based treatments for heart failure with reduced ejection fraction.
- To highlight the role of medications, devices, and management programs.
Main Methods:
- Review of randomized clinical trials and data on various treatment modalities.
- Analysis of drug classes, implantable devices, and patient management strategies.
Main Results:
- Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, vasodilators, beta blockers, and aldosterone antagonists consistently benefit mortality.
- Newer agents like angiotensin receptor/neprilysin inhibitors and sinus node modulators show promise.
- Implantable cardioverter-defibrillators and biventricular pacemakers improve outcomes in select patients.
- Disease management and telemonitoring reduce hospitalizations and mortality.
Conclusions:
- A multi-faceted approach combining guideline-directed medical therapy, devices, and supportive programs is essential for managing heart failure.
- Continuous evaluation of treatment efficacy and patient monitoring is key to reducing heart failure burden.
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