Related Experiment Video
Updated: Mar 9, 2026
09:42
Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
Published on: November 8, 2013
14.1K
A systematic review to assess adherence and persistence with statins
Sohan Deshpande1, Ruben G W Quek2, Carol A Forbes1
1a Kleijnen Systematic Reviews Ltd , York , United Kingdom.
Current Medical Research and Opinion
|January 12, 2017
Summary
Good adherence to statin therapy reduces cardiovascular events and mortality. Monitoring statin adherence is crucial for effective cardiovascular disease (CVD) management and reducing healthcare costs.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Health Services Research
Background:
- Statin therapy is a cornerstone in managing hypercholesterolemia and preventing cardiovascular events.
- Patient adherence and persistence with long-term medication regimens are critical for achieving therapeutic goals.
- Understanding factors influencing statin adherence is essential for optimizing patient outcomes.
Purpose of the Study:
- To systematically review and synthesize evidence on statin adherence and persistence.
- To evaluate the association between statin adherence/persistence and cardiovascular event risk.
- To summarize the methodologies, strengths, and limitations of existing studies.
Main Methods:
- A comprehensive literature search of electronic databases and conference abstracts was conducted from January 2005 to February 2016.
- Independent review and data extraction by two researchers ensured study selection and quality assessment rigor.
- Included studies focused on adult patients with primary hypercholesterolemia and reported on statin adherence or persistence.
Main Results:
- Eighty-four real-world studies were analyzed, predominantly showing that good statin adherence/persistence correlates with reduced cardiovascular events and mortality.
- Some studies indicated that high-intensity statin regimens may be associated with lower patient adherence compared to low-intensity regimens.
- Statin adherence and persistence significantly impact hospitalization and other cardiovascular disease-related costs.
Conclusions:
- Consistent adherence and persistence with statin therapy are linked to decreased cardiovascular events and mortality.
- Evidence regarding the impact of statin intensity on adherence is limited, necessitating further robust research.
- Clinicians and pharmacy managers should prioritize regular monitoring of statin therapy adherence, aligning with major clinical guidelines.
Related Concept Videos
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.6K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.6K
01:26Atherosclerosis III: Management
540
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
540
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
288
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
288
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
196
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
196
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
726
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
726
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
511
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
511