Related Experiment Video
Updated: Mar 8, 2026
An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
Published on: May 23, 2019
Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells
Sungsu Lim1, Md Mamunul Haque, Dongdong Su
1Korea Institute of Science and Technology (KIST), Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Seoul 136-791, South Korea. yunkyungkim@kist.re.kr.
Abstract:
Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
