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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Medication Nonadherence in Systemic Lupus Erythematosus: A Systematic Review
Pavandeep Mehat1, Mohammad Atiquzzaman1, John M Esdaile1
1University of British Columbia, Vancouver, and Arthritis Research Centre of Canada, Richmond, British Columbia, Canada.
Arthritis Care & Research
|January 14, 2017
Summary
Medication nonadherence is common in systemic lupus erythematosus (SLE), affecting over half of patients. Factors like depression and polypharmacy contribute to this issue, necessitating targeted interventions.
Area of Science:
- Rheumatology
- Pharmacology
- Public Health
Background:
- Medication nonadherence in systemic lupus erythematosus (SLE) is not well understood.
- Understanding nonadherence is crucial for improving patient outcomes in SLE.
Purpose of the Study:
- To systematically review the literature on medication nonadherence in SLE.
- To characterize the burden and identify determinants of nonadherence in SLE patients.
Main Methods:
- Systematic literature search of Medline, Embase, and Web of Science databases (1900-2015).
- Inclusion of original studies evaluating nonadherence to SLE therapies as a primary outcome.
- Extraction of data on study design, sample size, adherence measures, and determinants.
Main Results:
- Eleven studies met inclusion criteria, with sample sizes ranging from 32 to 246 patients.
- Nonadherence rates ranged from 43% to 75%, with over half of SLE patients being nonadherent.
- Key determinants included depression, rural residence, lower education, and polypharmacy; up to 33% discontinued therapy within 5 years.
Conclusions:
- A substantial burden of medication nonadherence exists in SLE.
- Interventions are needed to support adherence and improve treatment outcomes for SLE patients.
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