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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

9.5K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Production of Formed Elements01:34

Production of Formed Elements

5.2K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

10.8K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
10.8K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Lineage Commitment01:21

Lineage Commitment

4.5K
Commitment is the  process whereby stem cells:
4.5K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.2K

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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

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Clonal hematopoiesis.

Max Jan1, Benjamin L Ebert2, Siddhartha Jaiswal3

  • 1Department of Pathology, Massachusetts General Hospital, Boston, MA.

Seminars in Hematology
|January 17, 2017
PubMed
Summary
This summary is machine-generated.

Clonal hematopoiesis, the expansion of blood stem cells with cancer-associated mutations, is common in aging. This pre-malignant state increases risks for blood cancers, cardiovascular disease, and mortality.

Keywords:
AgingHematopoietic stem cellPre-leukemia

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Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
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Area of Science:

  • Genetics
  • Hematology
  • Oncology

Background:

  • Pre-malignant states preceding hematologic malignancies are challenging to identify.
  • Genomic studies reveal common, age-associated somatic mutations in blood DNA.
  • These mutations lead to the expansion of hematopoietic clones.

Purpose of the Study:

  • To review advances in understanding the genetic basis of clonal hematopoiesis.
  • To explore the link between clonal hematopoiesis and age-related diseases.

Main Methods:

  • Analysis of large-scale genomic studies of blood DNA.
  • Review of current literature on clonal hematopoiesis and associated diseases.

Main Results:

  • Clonal hematopoiesis is a common, age-associated phenomenon driven by somatic mutations.
  • It is linked to an increased risk of hematologic malignancies.
  • Clonal hematopoiesis is also associated with cardiovascular disease and overall mortality.

Conclusions:

  • Clonal hematopoiesis offers insights into pre-malignancy and organ dysfunction.
  • Further research is needed to understand its role in both malignant and non-malignant age-related diseases.