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Updated: Mar 8, 2026
Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain
Published on: October 29, 2017
Effects of Acyzol on Zinc Content in Rat Brain and Blood Plasma
A F Yakimoskii1,2, I I Shantyr3, M A Vlasenko3,4
1Laboratory of Physiology and Pathology of Motor Behavior, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia. jakin2010@gmail.com.
Abstract:
Zinc level in the blood plasma and brain of rats was studied by inductively coupled plasma mass spectrometry. Maximum amount of zinc was observed in the cerebellum (15.0±5.5 μg/mg wet tissue). Single intraperitoneal administration of a zinc donor acyzol (24 mg/kg) did not change the content of this element in the tissues. Repeated injections of acyzol (7 injections over 14 days) significantly increased zinc level in rat plasma and brain. This elevation was most pronounced in the forebrain (cortex and subcortical structures). The rise in zinc concentration in blood plasma correlated with its level in the brain.
