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Updated: Mar 8, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
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Hidden Markov Models for Protein Domain Homology Identification and Analysis

Karl Jablonowski1,2

  • 1Division of Emergency Medicine, Department of Medicine, University of Washington, 325 9th Ave., Seattle, WA, USA. kdj6@uw.edu.

Methods in Molecular Biology (Clifton, N.J.)
|January 17, 2017
PubMed
Summary

This study introduces Hidden Markov Models (HMM) for identifying protein domains. These models are effective for predicting and categorizing evolutionarily linked protein families, specifically Src Homology 2 (SH2) domains.

Keywords:
Hidden Markov modelNeighbor-joining phylogenetic treeSH2 domainsSequence alignment

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