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Related Concept Videos

Aging01:26

Aging

929
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

298
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
298
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

288
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
288
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

779
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Updated: Mar 8, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
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Environmental Chemicals and Aging.

Brandon L Pearson1, Dan Ehninger2

  • 1DZNE, German Center for Neurodegenerative Diseases, Sigmund-Freud Str 27, 53127, Bonn, Germany. brandon.pearson@dzne.de.

Current Environmental Health Reports
|January 20, 2017
PubMed
Summary
This summary is machine-generated.

Environmental chemicals and certain drugs can accelerate aging, especially in the brain, by impacting molecular aging pathways. Research highlights the need for better methods to identify and regulate these gerontogenic substances.

Keywords:
AgingBrainEnvironmental chemicalsGerontogenMitochondriaOxidative stress

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Area of Science:

  • Environmental Health
  • Toxicology
  • Neuroscience
  • Gerontology

Background:

  • Global population growth and aging necessitate innovations in agriculture, medicine, and technology.
  • These advancements often involve novel chemical agents with potential human health impacts.
  • Understanding chemical influences on aging is crucial for public health.

Purpose of the Study:

  • To review environmental chemicals and drugs that may exacerbate aging.
  • To focus on chemicals affecting molecular aging cascades, particularly in the brain.
  • To identify research areas for mitigating chemical toxic influences.

Main Methods:

  • Summarizing recent research on chemical impacts on aging.
  • Highlighting studies identifying agrochemicals linked to neurological diseases.
  • Analyzing mechanisms like free radical stress and mitochondrial dysfunction.

Main Results:

  • Certain environmental chemicals and drugs can accelerate biological aging.
  • Agrochemicals are identified as potential inducers of neurological diseases.
  • Elevated free radical stress and mitochondrial dysfunction are key mechanisms.

Conclusions:

  • Chemicals can accelerate aging, with significant brain implications.
  • Advanced molecular profiling can aid in prevention and mitigation strategies.
  • Improved methodologies are needed for identifying and regulating gerontogenic chemicals.