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Related Experiment Video

Updated: Mar 8, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Published on: November 15, 2017

Multi-step continuous-flow synthesis.

Joshua Britton¹, Colin L Raston¹

¹School of Chemical and Physical Sciences, Flinders University, Bedford Park, South Australia 5042, Australia. Colin.raston@flinders.edu.au.

Chemical Society Reviews

|January 21, 2017

Summary

This summary is machine-generated.

Continuous-flow chemistry enables efficient synthesis of complex organic molecules. This review highlights advancements in multi-step flow systems for producing valuable compounds like active pharmaceutical ingredients.

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Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

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Area of Science:

Organic chemistry
Chemical engineering
Synthetic chemistry

Background:

Organic chemistry syntheses are advancing, driven by new laboratory technologies.
Continuous-flow systems offer significant advantages over traditional batch methods (round bottom flasks).
Scaling up reactions is more manageable when considered early in the process.

Purpose of the Study:

To review advancements in multi-step continuous-flow systems.
To highlight the benefits and diversification of flow chemistry in organic synthesis.
To showcase applications in synthesizing active pharmaceutical ingredients, natural products, and commodity chemicals.

Main Methods:

Utilizing sequential transformations in continuous-flow systems to build molecular complexity.
Employing a mobile scaffold approach, analogous to in vitro Nature's polyketide synthases.
Reviewing literature on multi-step continuous-flow methodologies.

Main Results:

Continuous-flow systems facilitate the synthesis of value-added and bioactive compounds.
Multi-step flow systems are more valuable than single-step transformations for accruing molecular complexity.
This methodology has improved the synthesis of active pharmaceutical ingredients, natural products, and commodity chemicals.

Conclusions:

Multi-step continuous-flow systems represent a significant advancement in organic synthesis.
The field is rapidly progressing, offering diverse benefits and applications.
Flow chemistry is a powerful tool for efficient and scalable synthesis in modern chemistry.