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Updated: Mar 8, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain
Gyujin Park1, Tetsuhiro Horie1, Takashi Iezaki1
1a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
Abstract:
β-cryptoxanthin, a xanthophyll carotenoid, exerts preventive effects on various lifestyle-related diseases. Here, we found that daily oral administration of β-cryptoxanthin significantly ameliorated the development of tactile allodynia following spinal nerve injury but was ineffective in mechanical allodynia in an inflammatory pain model in mice. Our results suggest that β-cryptoxanthin supplementation would be beneficial for the prophylaxis of neuropathic pain.
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