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Quantification of multiple elements in dried blood spot samples.

Lise Pedersen1, Karen Andersen-Ranberg2, Mads Hollergaard3

  • 1Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark.

Clinical Biochemistry
|January 26, 2017
PubMed
Summary
This summary is machine-generated.

Dried blood spots (DBS) offer a convenient method for analyzing multiple elements. This study validates a precise and accurate DBS method, finding correlations with venous blood for elements like iron and zinc, and noting hematocrit

Keywords:
Dried blood spotsElementsHematocritICP-MSMethod validation

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Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Clinical Diagnostics

Background:

  • Dried blood spots (DBS) offer advantages over traditional blood collection for large-scale studies.
  • Development and validation of a novel method for multi-element determination in DBS are described.

Purpose of the Study:

  • To develop and validate a method for quantifying multiple elements in dried blood spots.
  • To assess the accuracy, precision, and reliability of DBS analysis compared to venous blood.

Main Methods:

  • Element extraction from DBS punches followed by analysis using inductively coupled plasma-mass spectrometry (ICP-MS).
  • Method validation using quality controls, spiked blood samples, and comparison with venous blood.
  • Assessment of hematocrit effects on element measurements in DBS.

Main Results:

  • The validated method demonstrated high precision and accuracy for most element measurements in DBS.
  • Significant, though weak, correlations were observed between DBS and venous blood for elements including Mg, K, Fe, Cu, Zn, As, and Se.
  • Hematocrit was found to influence DBS element measurements, particularly for potassium (K), iron (Fe), and zinc (Zn).

Conclusions:

  • Trace elements can be accurately measured in DBS with low imprecision, though filter paper signal can affect low-concentration elements.
  • The method is suitable for large population studies requiring multi-element analysis.
  • Simultaneous measurement of potassium (K) and iron (Fe) in DBS extracts can potentially estimate sample hematocrit.