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Related Experiment Video

Updated: Mar 8, 2026

An In Vitro Approach to Photodynamic Therapy
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Interstitial Photodynamic Therapy-A Focused Review.

Gal Shafirstein1, David Bellnier2, Emily Oakley3

  • 1Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. Gal.Shafirstein@RoswellPark.org.

Cancers
|January 27, 2017
PubMed
Summary

Interstitial photodynamic therapy (I-PDT) shows promise for treating advanced cancers, especially large or thick tumors. Optimizing I-PDT requires image-based planning and dosimetry, with CT imaging aiding response assessment.

Keywords:
brainhead and neckinterstitial photodynamic therapypancreaticprostatetreatment planning

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Area of Science:

  • Oncology
  • Medical Physics
  • Photochemistry

Background:

  • Interstitial photodynamic therapy (I-PDT) is a recognized treatment for locally-advanced tumors.
  • Current utilization of I-PDT is restricted to specialized medical centers.
  • Effective photosensitizers are available or under investigation for various cancers.

Purpose of the Study:

  • To review I-PDT administration approaches for specific cancers.
  • To highlight photosensitizers used in clinical trials and approved for use.
  • To discuss the potential of I-PDT for large-volume or thick tumors.

Main Methods:

  • Focused review of clinical studies and literature.
  • Analysis of I-PDT techniques for prostate, pancreatic, head and neck, and brain cancers.
  • Examination of photosensitizer applications in I-PDT.

Main Results:

  • I-PDT demonstrates significant potential for treating large-volume or thick tumors.
  • Various administration techniques for I-PDT have been employed.
  • Computed tomography (CT) imaging can be used for treatment planning and response assessment.

Conclusions:

  • I-PDT is a promising therapeutic option for advanced cancers, particularly large or thick tumors.
  • Advancement of I-PDT requires image-based treatment planning and real-time dosimetry.
  • CT imaging plays a role in assessing treatment response to I-PDT.